One keystroke beats hunting for an icon
If there is an extension you reach for constantly -- a clipboard manager, a translator, a screenshot tool -- clicking its toolbar icon every single time adds up. A dedicated keyboard shortcut turns that into a single reflexive keystroke, which matters more than it sounds like over a full day of work.
Global scope can collide with other software
Setting a shortcut to "Global" means it fires even when Chrome is not the focused window, which is convenient but risks colliding with a shortcut some other application already uses. Scoping it to "In Chrome" instead avoids that conflict entirely, at the cost of only working while Chrome is active.
Frequently Asked Questions
What if the shortcut I want is already used by another program?
A "Global" shortcut can conflict with another program's shortcut, so it is safer to pick a combination that is rarely used elsewhere, or scope it to "In Chrome" only.
How do I remove a shortcut I already set?
Click the input field, then press Backspace or Delete to clear the assigned shortcut.